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Acute Liver Failure

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ALF is a liver dysfunction syndrome that occurs within 8 weeks of symptom onset or liver disease. It is accompanied by uncorrectable coagulopathy and can occur without evidence of chronic liver disease.

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Acute Liver Failure PPT Summary

  1. Acute Liver Failure (ALF) is a clinical syndrome characterized by liver dysfunction, uncorrectable coagulopathy, and absence of chronic liver disease.
  2. The etiology of ALF varies depending on age, with viral hepatitis being the most common cause in adults and drugs being the predominant cause in children.
  3. Clinical presentation of ALF includes jaundice, encephalopathy, poor feeding, irritability, and seizures.
  4. Diagnostic work-up involves various blood tests and specific tests based on the suspected etiology.
  5. The management of ALF aims to prevent complications, assess prognosis, and consider liver transplantation if necessary.


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