Infective Endocarditis in Children

Infective Endocarditis in Children PPT Summary

1. The incidence of infective endocarditis in children has been increasing since the 1980s, likely due to factors such as an increasing number of surgical patients, complex congenital heart disease, and the use of prosthetic materials.
2. In the pre-antibiotic era, the mortality rate of infective endocarditis approached 100%, but it is currently around 15-25%.
3. Clinical features of infective endocarditis include febrile illness, persistent bacteremia, and the presence of characteristic lesions called vegetations on the endothelial surface of the heart.
4. Diagnosis of infective endocarditis is traditionally based on positive blood cultures in the presence of a new or changing heart murmur, but there can be limitations such as culture-negative endocarditis or lack of typical echocardiographic findings.
5. The goals of therapy for infective endocarditis include eradicating the infection and treating the destructive intra-cardiac and extra-cardiac lesions.

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