Major Histocompatibility Complex

Major Histocompatibility Complex PPT Summary

1. MHC, also known as HLA, is involved in graft rejection, cell-mediated cytolysis, and graft-versus-host reactions.
2. MHC I is found on all nucleated cells and is recognized by CD8 T cells when presented with an antigen.
3. MHC II is more restricted in distribution and is found on immune system cells.
4. HLA testing has clinical applications in organ transplantation, platelet donor selection, and genetic identification.
5. MHC has contributed to the understanding of cellular growth control pathways and cancer biology.

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