The major histocompatibility complex (MHC), also known as the Human leukocyte antigen (HLA), plays a crucial role in immune responses and is involved in graft rejection, cell-mediated cytolysis, and graft-versus-host reactions.
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Major Histocompatibility Complex PPT Summary
- MHC, also known as HLA, is involved in graft rejection, cell-mediated cytolysis, and graft-versus-host reactions.
- MHC I is found on all nucleated cells and is recognized by CD8 T cells when presented with an antigen.
- MHC II is more restricted in distribution and is found on immune system cells.
- HLA testing has clinical applications in organ transplantation, platelet donor selection, and genetic identification.
- MHC has contributed to the understanding of cellular growth control pathways and cancer biology.
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